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KMID : 0357920070410050324
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Korean Journal of Pathology
2007 Volume.41 No. 5 p.324 ~ p.328
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wist Expression in Upper Urinary Tract Urothelial Carcinoma Affects Patients Disease Free Survival and is Associated with Tumor Grade
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Kim Dong-Il
Moon Kyung-Chul
Yoon Sun-Och
Kim Bo-Mi
Kang Gyeong-Hoon
Park Seog-Yun
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Abstract
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Background : Epithelial-mesenchymal transition (EMT) is critical for morphogenesis during embryonic development and is also implicated in the conversion of early-stage tumors into invasive malignancies.
Recently, Twist has been identified to play an important role in EMT-mediated metastatic progression of several types of human cancer. The present study examined the expression of Twist and evaluated its clinicopathologic significance in urothelial carcinoma of upper urinary tract.
Methods : Immunohistochemical staining for Twist expression was performed on 70 upper urinary tract urothelial carcinomas (UUT-UCs) using tissue microarray.
Results : Immunohistochemical staining for Twist was positive in 31/70 cases (44.3%) of UUT-UCs. Twist expression was associated with high-grade and advanced-stage (ISUP grade, p<0.01; stage, p=0.045). The patients with Twist positive-tumors revealed lower disease free survival rate than those with Twist negative-tumors (p<0.01). The overall survival for patients with Twist positive-tumors was slightly worse than the patients with Twist negative-tumors, but the difference was not statistically significant (p=0.12).
Conclusion : Our results suggest that Twist is a novel marker for advanced UUT-UC.
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KEYWORD
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Carcinoma, transitional cell, Twist transcription factor, Disease free survival
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